Background: The current study is to evaluate cardiovascular effects of anesthetic medications and volatile anesthetics on cardiac stress using cardiac stress index (CSI) and rate pressure PRODUCT (RPP) and to determine which of them in useful in evaluating cardiac stress after comparing results obtained from each method.Materials and methods: 40 patients, 60-80 years old, who were all performed trans abdominal prostatectomy were studied. Patients were divided into two groups, half of patients were placed in group A and the other half in group B. The study was carried out as a blinded study. CSI was measured and evaluated in group A and RPP changes were studied in group B.Results: The mean CSI were 60.25±5.57, 63.05±5.54, 55.75±4.78 and 67.65±4.88 before anesthesia induction, after induction, before surgical incision and in recovery respectively. There was no meaningful difference.RPP mean in four above mentioned stages was 10.15±0.44, 9.9±0.69, 6.8±0.36 and 9.2±0.61 respectively. There was a meaningful difference between RPP in stages before anesthesia induction and before surgical incision (P<0.0001).Conclusion: Considering the obtained results from this study, it can be seen that even in noncardiac surgery, the stress level is high in patients in the stage before surgery. This figure was not clear in RPP index case and was not in accordance with CSI, which means CSI has been able to illustrate existing stress level better and efficiently.